But Liverpool were level just four minutes later when Luis Diaz converted Dominik Szoboszlai’s cross from close range. The offside flag went up but VAR awarded the goal.
The momentum was now all with Liverpool and the home side took the lead in the 24th minute when Alexis Mac Allister thundered the ball home from the 18-yard line past the flying Guglielmo Vicario.
Now the party was well and truly started and Gakpo made it 3-1, slamming a shot into the bottom corner after Spurs failed to clear.
Tottenham manager Ange Postecoglou had made eight changes from the team that lost to Nottingham Forest last week as he prioritises the semifinals of the Europa League, and they now had a mountain to climb.
The Liverpool fans, deprived of celebrating the 2020 Premier League trophy because of Covid restrictions, ran through their full repertoire of songs as their team pushed for a fourth goal in the second half.
Top-scorer Salah scored the goal the crowd craved, collecting Szoboszlai’s pass before cutting in and blasting his shot into the bottom corner.
He celebrated by grabbing a fan’s phone before taking a selfie in front of the Kop.
Deafening cheers of “We’re going to win the league” and “We shall not be moved” rang out.
Liverpool had a fifth when Spurs defender Destiny Udogie poked the ball past his own goalkeeper from close range with about 20 minutes to go as the game turned into a procession.
As the game went into added time, the club’s anthem rang out again as scarves were held aloft and the final whistle elicited a thunderous roar.
The win leaves Liverpool on 82 points, 15 clear of nearest challengers Arsenal with just four games remaining.
Tottenham are a miserable 16th in the Premier League table after their 19th defeat of the season, putting Postecoglou under enormous pressure.
Tens of thousands of fans swarmed around Anfield in the build-up to kick-off in anticipation of Liverpool’s coronation, setting off flares as the home team bus arrived.
Flags and scarves saying “Liverpool 20-time Champions” were on sale from stalls outside the ground.
At the start of the campaign, Pep Guardiola’s Manchester City were favourites to extend their dynastic Premier League reign and make it five titles in a row but their form collapsed.
Arsenal emerged as their closest challengers but they drew too many games, failing to take advantage of the rare Liverpool slip-ups.
It was feared Liverpool’s players would need time to adapt to the methods of Slot, who replaced Jurgen Klopp last June following the German’s departure after nine trophy-filled years at Anfield.
But the former Feyenoord boss has sailed serenely through the season despite relentless speculation over the futures of three of his biggest stars – Salah, captain Virgil van Dijk and Trent Alexander-Arnold.
Both Salah and Van Dijk have now signed two-year extensions, though England defender Alexander-Arnold is believed likely to be on the verge of a move to Real Madrid.
